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It is important to note that, despite these convergent findings, direct mechanistic evidence demonstrating that addictive substances induce depressive phenotypes via specific epigenetic pathways remains extremely limited, with only a few studies providing clear causal links

Salidroside, a phenyl ethanol glycoside from Rhodiola crenulata, orchestrates hypoxic mitochondrial dynamics homeostasis by stimulating Sirt1/p53/Drp1 signaling

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The most consistent problem was the near-total absence of human clinical trial data for the proposed injectable routes