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& Natali, M

In acute myeloid leukemia (AML), gold nanoparticles (AuNPs) were modified by encapsulating anti-miR-221 and adding to their surfaces DNA aptamer AS1411, which can interact specifically with nucleolin in AML cells, thereby targeting the nucleolin/miR-221/NF-B/DNMT1 signaling pathway responsible for leukemogenesis (Deng et al

The technique was developed in 1960s, with the first specialized SANS diffractometers being developed at the Jlich research center in Germany in the early 1970s (Jacrot, 1976)