These are the building blocks your fibroblasts need to make new collagen, but are in short supply in normal diets (because we dont eat lots of animal hide or gristly bits)
Numbuzin No.5+ Glutathione Vitamin Concentrated Serum ingredients (INCI) Vaccinium Vitis-Idaea Fruit Extract, Butylene Glycol, Niacinamide, Panthenol, Tranexamic Acid, Water, 1,2-Hexanediol, Neopentyl Glycol Dicaprate, Caprylic/Capric Triglyceride, Sorbitol, Bifida Ferment Lysate, Chondrus Crispus Extract, Butyrospermum Parkii (Shea) Butter, Saccharum Officinarum (Sugar Cane) Extract, Alpha-Arbutin, Sodium Hyaluronate, Melia Azadirachta Flower Extract, Ocimum Sanctum Leaf Extract, Melia Azadirachta Leaf Extract, Curcuma Longa (Turmeric) Root Extract, Corallina Officinalis Extract, Tremella Fuciformis (Mushroom) Extract, Pentylene Glycol, Glycerin, 3-O-Ethyl Ascorbic Acid, Bisabolol, Tromethamine, Ethylhexylglycerin, Adenosine, Hydrogenated Lecithin, Allantoin, Glutathione, Ceramide NP, Beta-Glucan, Dipotassium Glycyrrhizate, Tocopherol, Ascorbic Acid, Ascorbyl Glucoside, Tocopheryl Acetate, Hydroxypropyl Cyclodextrin, Ubiquinone, Lipoic Acid, Potassium Hydroxide, Behenyl Alcohol, Carbomer, Xanthan Gum, Disodium EDTA
In addition, the treatment of nicotinamide (NAM), a form of vitamin B3, suppressed the activity of sirtuin-1 (SIRT1), a regulator of cellular stress resistance, and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1), a key transcriptional coactivator involved in mitochondrial biogenesis and energy metabolism
Cynaroside blocked the activation and development of liver fibrosis by inhibiting the overexpression of FGFR2 and the excess of basic fibroblast growth factor (bFGF), thus reducing hepatic stellate cell (HSC) activation and collagen secretion in hepatocytes (Sato-Matsubara et al., 2017
