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Consequently, the patient experiences a significant decrease in the international normalized ratio, placing them at increased risk for thrombotic complications such as mechanical valve thrombosis unless the warfarin dose is appropriately escalated

10.1038/nsb789 [DOI] [PubMed] [Google Scholar] Tsui WC, Fersht AR

2006 Dec;291(6):E1290-4

Periventricular leukomalacia Periventricular leukomalacia (PVL) is a diffuse damage of the cerebral white matter that extends beyond the periventricular regions found predominantly in preterm infants