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Nuclei were counterstained with hematoxylin (for IHC) or DAPI (for Tunel)

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Collectively, GGCT emerges as a pivotal metabolic orchestrator in HCC and PCa, functioning as a bidirectional switch that diverts Gln toward GSH biosynthesis for redox defense while enhancing Glc-fueled TCA anaplerosis to sustain cell proliferation

*Correspondence: Javier Blesa, Centro Integral de Neurociencias A.C., HM Puerta del Sur, Hospitales de Madrid, Mstoles and Medical School, CEU San Pablo University, Avenida de Carlos V, 70, 28938 Mstoles, Madrid, Spain, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers