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Generally, proteins of the GPX family are characterized either as selenoproteins or non-selenoproteins depending if they have in their catalytic sites the amino acid residue selenocysteine (SeCys) encoded by the UGA codon or the cysteine (Cys) encoded by the UGU or UGC codon (Trenz et al., 2021)

This phenomenon could be further exacerbated by the depletion of the methyl donor S-adenosylmethionine (SAM) pool, as a consequence of VitB12 deficiency, a universal methyl donor needed for the methylation of DNA, RNA, proteins, neurotransmitters, and phospholipids