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For amyotrophic lateral sclerosis (ALS), current guidelines recommend at least molecular analysis of C9ORF72, SOD1, FUS, and TARDBP (Roggenbuck et al., 2023)

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Cancer 1 , 315328 (2020)

Despite the widespread use of serotonergic medications, benzodiazepines and cognitive behavioral therapy (CBT), therapeutic outcomes remain limited with less than 50% of patients reaching full remission and nearly one-third do not respond to conventional treatments (De Vries et al., 2016)