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Unlike the Phoqus formulation, which appeared to transit the gastrointestinal (GI) tract slower and more predictably than multi-particulates, the rapid transit of the multi-particulates we presumed had resulted in the majority of the drug payload being delivered to the colon, a region of the GI tract wherein the absorption of hydrocortisone had not been formally studied

and (4) ablation of Slc7a11 in endothelium aggravated but inhibition of miR-30e-5p in adipose tissue alleviated atherosclerosis in mouse models (illustrated in Figure 8)