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Peer review Peer review information Nature Reviews Neurology thanks Hlio Teive, Ludger Schls and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

5 Neutrophil metabolic alterations in the context of inflammation and atherosclerosis Neutrophils contribute to the development of atherosclerosis and the destabilization of plaques (Soehnlein, 2012)

In T2DM, LDL is frequently found in its glycated form [36]

Furthermore, iron response element binding protein 2, a major transcription factor involved in iron metabolism, can significantly increase FTL and FTH1 expression, thus inhibiting erastin-induced ferroptosis 8