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It is extensively involved in the synthesis and catabolism of carbohydrates, lipids and proteins

Patients with dissection (n = 125) had significantly increased values of ICA tortuosity compared to healthy controls (n = 24) (OR 2.65[CI 1.68-3.86], p 100 mmHg) at randomization

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In the ETC, complexes donate electrons to oxygen producing radicals like superoxide and peroxidases, and high levels of such radicals and oxidative stress cause damage to lipids, enhance DNA breaks, and oxidize nuclear and mtDNA (Tobe, 2013