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The chief pathological changes in RA involve synovitis and the formation of vascular pannus, leading to progressive destruction of joint cartilage and bone tissue (Huang et al., 2021)

Necrosis , on the other hand, is considered to be unregulated, random cell death caused by non-specific or non-physiological stress factors, characterized by swelling of cellular organelles, rupture of the plasma membrane, and subsequent inflammatory responses due to the release of intracellular contents

I am thankful that my mom (retired MD and RN, and co-author of Hashimotos: The Root Cause ), helped me track down some studies of how high altitude hypoxia could lead to iron overload

Hamza A, Amin A, Daoud S