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The accumulation of A in astrocytes is responsible for increased ROS production and decreased glutathione levels, leading to oxidative stress and neuronal vulnerability (Allaman et al., 2010)

Group 2 (depressed group): Rats were intraperitoneally (i.p.) administered reserpine (0.2 mg/kg b.wt.) for 14 days and then (0.1 mg/kg b.wt., i.p.) for four weeks (Antkiewicz-Michaluk et al., 2014)

H2O2 when accumulated is toxic to body tissues or cells

Relationships between body mass index and constipation, gastroesophageal reflux disease, stool forms based on the bristol stool form scale, and education level: results from an internet survey in Japan