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Additionally, ethanol binge drinking induces neuroinflammation, such as indicated by the activation of innate immune receptors TLRs and by an increase in the expression of the inflammatory cytokines TNF and IL-1, and demyelination suggested by significantly reducing the levels of the myelin proteins myelin basic protein (MBP) and myelin oligodendrocyte glycoprotein (MOG) in the prefrontal cortex [123]

Also, another randomized double-blind study compared the efficacy of 100 mg diclofenac sodium soft gel (with or without 100 mg caffeine) with placebo during migraine attacks

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