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This action is possible due to their capacity to inhibit pathways that trigger oxidative stress, and the synthesis and release of cytokines and chemokines, which are proinflammatory chemicals

Zebda R, Paller AS (2018) Phosphodiesterase 4 inhibitors

The legitimate worry with sustained NNMT inhibition isnt tolerance in the receptor sense

6,11 Areas of interest include oxidative stress, chronic low-grade inflammation, mitochondrial dysfunction, and central sensitization mechanisms that contribute to neuropathic pain