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demonstrated a two-fold elevation in the activity and the level of BACE1 in AD patients (Vassar et al., 2009)

It is also a precursor for the synthesis of nitric oxide, a neurotransmitter that promotes vasodilation

It is called mitochondrialderived because it is encoded by mitochondrial genetic material and is studied as part of how mitochondria may send signals that influence cellular behavior in experimental models

KEGG enrichment analysis revealed that the core pathways were primarily associated with inflammatory response and oxidative stress, including the PI3K-Akt signaling pathway, MAPK signaling pathway, Chemokine signaling pathway, Chemical carcinogenesis - reactive oxygen species, TNF signaling pathway, Th17 cell differentiation, mTOR signaling pathway, and IL-17 signaling pathway (Fig