glutathione peroxidase type 2 Frontiers Glutathione peroxidase 4 inhibition induces

Lipid peroxide accumulation results from enzymatic and non-enzymatic processes (Rochette et al., 2022)

Factors such as rectal irritation, lesions, or recent surgery may affect the suitability of this route of administration

*Correspondence: Viviana Trezza [email protected] Piemonte [email protected] These authors share first authorship These authors share last authorship This article was submitted to Molecular Psychiatry, a section of the journal Frontiers in Psychiatry Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

These chemical or physical modifications of small molecule ferroptosis modulators improve their bioavailability and targeting, and significantly increase their clinical application potential