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In the prospective Framingham Offspring Study, moderately elevated bilirubin concentrations were found to be associated with a lower risk of cardiovascular disease, coronary heart disease and myocardial infarction ( 90 )

Considering the structure of 2-AB, we hypothesized that 2-AB is generated by an amino group transfer reaction to 2-OBA by amino transfer enzymes, such as aspartate aminotransferase (AST)

Moreover, although PET-based fluorescence switching enables effective off-on activation, the extent of initial quenching and the magnitude of signal recovery upon activation are highly dependent on the COFs electronic structure and local microenvironment, necessitating precise molecular engineering to balance diagnostic signal-to-noise ratio with therapeutic output

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