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These effects, in conjunction with potential sleep-enhancing benefits observed in patients with dementia treated with melatonin [214], provide a compelling rationale for hypothesizing that supplementing melatonin near bedtime may augment the glymphatic systems clearance function

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In conclusion, we have reviewed the literature, which supports the idea that microglial activation is important in PD progression and have shown that the PD-related protein, -synuclein, incites an increase in antioxidant response enzyme expression in vivo and in cultured microglia