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Collectively, these clinical experiences highlight a key translational challenge: even when therapeutic targets are biologically validated, inefficient CNS delivery limits treatment efficacy while increasing systemic burden

[DOI] [PubMed] [Google Scholar] 70.Kwong AKY, et al

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Biochim Biophys Acta 1824:157163 Herrera MG, Pizzuto M, Lonez C, Rott K, Htten A, Sewald N, Ruysschaert JM, Dodero VI (2018) Large supramolecular structures of 33-mer gliadin peptide activate toll-like receptors in macrophages