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One technological solution involves the use of a GRAS strain, Lactobacillus paracasei , engineered to express exenatide

(PubMed) Dalmeijer GW, Olthof MR, Verhoef P, Bots ML, van der Schouw YT

Other botanical compounds act as insulin mimetics, meaning their molecular structure is similar enough to insulin that they can independently activate cellular receptors and facilitate glucose uptake, even when the body's own insulin signaling is impaired