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257 Due to these backbone modifications, PNAs show improved resistance to nuclease and protease digestion

The majority of renoprotective claims derive from rodent models (primarily db/db mice, streptozotocin-induced diabetes, or high-fat diet models), which exhibit fundamental differences from human DKD in gut microbiota composition, metabolic kinetics, and disease progression timelines

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Studies show that B12 has a role in keeping nerves healthy and supporting brain function when someone has a deficiency