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Coenzyme Q10 (CoQ10) and L-carnitine are naturally occurring compounds that play essential roles in cellular energy production

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The calcium overload activates calcium-dependent enzymes (e.g., calpain, nitric oxide synthase [NOS]), generating ROS and mitochondrial dysfunction, which triggers the release of apoptosis-inducing factor and cytochrome C, thereby activating caspase-9 and caspase-3