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These diagnostic applications can be used, for example, to assess cardiac physiology, respiratory physiology, muscle strength, and muscle endurance (Duren et al., 2008

Proinflammatory cytokines from macrophages contribute to beta cell loss in type 1 diabetes, exemplified by the protective effects of deleting NLR family pyrin domain containing 3 (NLRP3) inflammasome in NOD mice and inhibiting TNF in humans with recent-onset type 1 diabetes [5,6,7]