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They highlight that inadvertent intravascular injection, high cumulative dosing, and patient factors (extremes of age, cardiac, hepatic, or renal disease, pregnancy) are major contributors, and that bupivacaine carries the greatest cardiotoxic risk

faecium are related to translation, oxidative stress management, protein folding and stability, biofilm formation capacity, glycine metabolism and osmoprotection

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First, oxaliplatin both increased the expression of the M2 acetylcholine receptors and decreased acetylcholine levels in the posterior insula whereas either activating the M2 receptor or restoring acetylcholine levels specifically in the posterior insula reversed CIPN symptoms (Kanat et al., 2013)