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The finding that sleep deprivation leads to lower cortisol levels post deprivation (primarily during the subsequent night of sleep) suggests that lowering the level of HPA activity, which is increased in depression, may be the mechanism through which sleep deprivation improves the mood of depressed individuals

There is also a low rate of gut microbial richness and specific bacterial groups are enriched or decreased in obese patients in comparison with lean people (246)

3 December 2020

These binding events are enriched in motifs recognized by tissue-specific TFs and associated with increased enhancer activity and gene expression in the same tissue (Bridoux et al, 2020a