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Patients whove gone through treatment will often say your symptoms get worse before they get better. One of the reasons for this is something called a Jarisch-Herxheimer reaction

Pourtaheri N

10.1126/science.aau9540 [DOI] [PubMed] [Google Scholar] Johnston NR, & Strobel SA (2020)

5-(1-Pyrrolyl)-thieno [2, 3-d] pyrimidine as Building Block in Heterocyclic Synthesis: synthesis of some new 6-Substituted 5-(1-pyrrolyl)-thieno [2, 3-d] pyrimidines and 5 (4)-Substituted pyrimido-[2, 3: 4, 5] thieno [2, 3-e] pyrrolo [1, 2-a] pyrazine Der