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Nevertheless, its effectiveness remains limited by the intestinal mucosa's low permeability, which restricts drug absorption and overall bioavailability

Muttigi MS, Han I, Park H-K, Park H, Lee S-H

10.1124/jpet.105.097139 J

On the experimental day, cells were washed twice and placed into KRB buffer (132.2 mM NaCl, 3.6 mM KCl, 5 mM NaHCO 3 , 0.5 mM NaH 2 PO 4 , 0.5 mM MgCl 2 , 1.5 mM CaCl 2 and 0.001 g/mL BSA, pH 7.4) supplemented with 25 mM glucose (1 h, 37 C, 5% CO 2 )