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Description

J Pharm Pharmacol 67:673684 Repka MA, Battu SK, Upadhye SB, Thumma S, Crowley MM, Zhang F, Martin C, McGinity JW (2007) Pharmaceutical applications of hot-melt extrusion: part II

Delivering therapeutic agents to their target sites presents several challenges, including poor bioavailability, in vivo instability, low solubility, limited absorption, target-specific delivery difficulties, and suboptimal therapeutic efficacy