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doi: 10.1016/S0022-3476(09)90024-5 129 FowdenALForheadAJ

NAD(P) + : oxidized nicotinamide adenin dinucleotide (phosphate), Nrf2: nuclear factor erythroid 2-related factor 2

However, as detailed above, cells that exhibit higher levels of mitochondrial activity are less sensitive to 5FU treatment, and those with compromised mitochondrial function are more sensitive, correlating with intrinsic resistance