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The efficacy of targeted therapies and immunotherapies is commonly compromised by the emergence of drug resistance and other factors, resulting in a lack of durable therapeutic benefits

This process is complex, other proteins are involved in it (e.g

44,223,224,225 After stroke, astrocytes can undergo variable changes that may result in glucose hypometabolism that reduces the function neighbouring neurones 70 but may also protect synapses and promote plasticity