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Since alcohol and caffeine are potential triggers, it could be helpful to significantly reduce or eliminate them to see if they are involved in the RLS symptoms

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Underneath the epithelium, the lamina propria provides defense based on innate and acquired immunity cells such as dendritic cells, B-cells, T-cells and macrophages

Cell 117(3):399412 Stitt TN, Drujan D, Clarke BA, Panaro F, Timofeyva Y, Kline WO, Gonzalez M, Yancopoulos GD, Glass DJ (2004) The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors