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Contributions of neurotropic human herpesviruses herpes simplex virus 1 and human herpesvirus 6 to neurodegenerative disease pathology

Such insights guide rational development: one can prioritize compounds that hit multiple synergistic targets or design combination therapies that harness beneficial polypharmacology while minimizing promiscuous interference

That is the evidence gap, stated plainly: the mechanism is well-motivated and the preclinical signal is consistent, but no human study has confirmed that any of it translates to people, at any dose, by any route