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doi: 10.1016/j.joca.2014.12.019

IGF-1/IGF-1R induces differentiation rather than proliferation when the cells do not express or underexpress insulin receptor substrate-1 (IRS-1), a docking protein for both IGF-1R and the insulin receptor that is known to send a mitogenic, anti-apoptotic and anti-differentiation signal 35,36

However, this study has several limitations: the retrospective nature of the analysis limits the generalizability of the results

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