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10.1053/jhsu.2003.50052 63 ThomopoulosS.HarwoodF

Especially, AMPK is a potent inhibitor of the mTOR-mediated signaling, e.g., it can inhibit the MDSC-induced immunosuppressive responses, probably inhibiting the mTOR-STAT3 pathway [64]

Dosing Protocol Suggested administration approaches

For example, the BIF peptides BIFP and BIFY bind to RANK and RANKL, effectively blocking the RANK-RANKL interaction, and further attenuating osteoclast activity to promote bone regeneration [94]