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Ethics declarations Competing interests MP is a consultant for Ferring Pharmaceuticals, Inc, Salvo Health, Dieta Health, and Vivante Health, Inc has received grant support from Bausch Health, and has equity in Gemelli Biotech, Dieta Health, Salvo Health, Vivante Health, and Good LFE

Clinical importance of folate cycle inhibitors and synthesis of dTMP Synthesis of dTMP for DNA synthesis is the rate-limiting step for the replication process, and therefore disruption of this conversion is very effective at reducing cellular proliferation

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L-glutathione helps to lighten skin by inhibiting melanin (a pigment responsible for skin colour) formation