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doi: 10.3390/ijms22168819 15 JacksonH

Nonetheless, NAPQI binding to mitochondrial proteins correlates with APAP toxicity30, and hence the effect could be a cumulative one, with mitochondrial function being affected once a threshold of mitochondrial protein modification is attained

Li F, Jiang T, Li Q, Ling X (2017) Camptothecin (CPT) and its derivatives are known to target topoisomerase I (Top1) as their mechanism of action, did we miss something in CPT analogue molecular targets for treating human disease such as cancer