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In contrast, aged animals exhibited no significant changes in macrophage cytokine levels, suggesting that Epitalons therapeutic value may lie more in correcting age-related immune deficits than in stimulating already functional systems

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Interest accelerated after Russian aging researchers proposed that Epitalon might influence cellular aging pathways through effects on telomerase activity, pineal gland signaling, oxidative stress, and circadian regulation

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The method of any one of embodiments 79-89, wherein the therapeutic agent is a TRPV modulator

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