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Teng C, Egger S, Blinman PL, Vardy JL

Doubling the dose after a missed injection does not compensate for the methylation gap because methyl donor pathways saturate at physiological thresholds

129 HornigM.GottschalkC

In vitro exposure to SeNP can increase levels of H3K4me3, H3K27me3, and H3K9me2 [40], and decrease H3K9me3 methylation [61], imparting a global rather than specific effect on histone methylation