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Description

It was subsequently found that for peptide substrates use of N -methyl-2-pyrrolidone (NMP) as a solvent offered improved yields

It is also involved in different brain-related diseases 56

Activation of PDHK1 inhibits pyruvate dehydrogenase (PDH), thereby inhibiting the production of acetyl-CoA from pyruvate and redirecting it toward lactic acid production instead