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On the next day, cells were transfected with SOD1 WT (1 ug) or SOD1 G93A (1 ug) using transfection reagent Lipofectamine 2000 (ThermoFisher Scientific, Waltham, MA)

Metabolomic response of human skin tissue to low dose ionizing radiation

The kynurenine pathway (KP), which catabolizes over 95% of tryptophan via indoleamine 2,3-dioxygenase 1 (IDO1)/ tryptophan 2,3-dioxygenase (TDO), further modulates fibrosis