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flavonoids, iso-flavonoids), carotenoids (e.g

Cancer Cell 15 , 232239 (2009)

It is imperative to emphasize that the emerging IRS-CIRS profile in severe MDD markedly diverges from the characterization established in the 1990s, as well as from the mainstream paradigm, which predominantly involves inflammation (increases in IL-6, TNF-, and CRP levels) in inflammatory depression