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Endocrine, Metabolic & Immune Disorders-Drug Targets (Formerly Current Drug Targets-Immune, Endocrine & Metabolic Disorders) 8(3): 159172

Fifth, disrupted mitochondrial dynamics refers to imbalance between fission (mediated by Drp1) and fusion (mediated by Mfn1/2 and OPA1), leading to mitochondrial fragmentation and functional decline (Chen W