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However, the cause of the density decrease must be first elucidated, whether is caused by a direct cell death already shown in previous studies 37,38,39 , whether is due to an impairment on the remarkable neurogenic role of hippocampus, especially the latter, considering the period of fluoride exposure ended with the CNS fully developed 29 , with 81-days-old, which corroborates with the dual suggestive pathways of our findings regarding the developmental fluoride neurotoxicity 30,40

GSTA2 S112T polymorphism associated with HCC recurrence and survival There were 12 differential SNPs in GSTA2 transcript identified by RNA sequencing between recipients with and without HCC recurrence (Supplementary Table S3)