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The reaction rate is influenced by the nucleophilicity of the thiolate, resulting in the enhanced capacity of NAC for reducing disulfide bonds compared to cysteine and GSH (Noszl et al., 2000)

The local inflammatory response supports the formation of drusen, contributes to degeneration of the RPE and adjacent photoreceptors, and disrupts Bruchs membrane which, in wet AMD, allows the ingrowth of neovascular vessels into the subretinal and/or sub-RPE space (Figure 2)

The peptides were eluted onto an EASY-Spray HPLC column (Thermo ES902, ES903) using an Acclaim PepMap 100 (Thermo 164535) loading column and separated at a flow rate of 0.25 L/min