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For example, in mouse embryonic stem cells, excess 2-OG maintains pluripotency dependent on the 2-OG/succinate ratio by increasing TET and KDM activity 45

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These compounds work through independent mechanisms, meaning they can potentially be used together under physician supervision without pharmacological conflict

These results from both transcriptomic analysis and qRT-PCR indicated that the combination of (-)-Vestitol and Salviolone synergistically regulated the expression of the Glp1r , Htr4 , Ntsr1 , Nos1 , and Ntrk1 genes within the Neuroactive ligand-receptor interaction and Calcium signaling pathway