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9,13 Other mechanisms of hepatotoxicity include the formation of toxic free radicals, such as peroxynitrite, from the reaction of superoxide and nitric oxide, subsequently forming nitrotyrosine adducts inside the mitochondria

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Recommendation 5: Liver biopsy should be considered in HCC patients receiving molecular targeted therapy and/or ICIs under the following conditions: (1) Liver injury cannot be clearly attributed to anti-tumor therapy, necessitating further investigation