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Subsequent research studies have confirmed that the levels of ROS in AD patients are increased, and in severe clinical cases, the protein folding function of the endoplasmic reticulum is impaired, and the clearance of damaged proteins mediated by proteases and autophagy is reduced, which promotes the accumulation of amyloid- (A ) and TAU proteins 37

J Diet Suppl 21(2):210241 Zin MT, Kaewkod T, Chaipoot S, Kanthakat G, Chen Y-Y, Cheirsilp B et al (2025) Ultrasound-assisted deep eutectic solvent extraction of antioxidant and anti-colorectal cancer proteins from Spirulina biomass: process intensification, characterization, and bioactivity evaluation