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The de novo pathway uses tryptophan as a starting point, while the salvage pathway recycles nicotinamide - one of three major precursors along with tryptophan and nicotinic acid

doi: 10.1093/nar/gkac885

It reduces methylationdriven consumption of NAM, increases substrate availability for NAD+ synthesis, and promotes NAD+ biosynthesis to elevate intracellular NAD+ levels