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PMID: 1261644 Barnes CA, McNaughton BL, OKeefe J (1983)

They monitored IGF-1 levels, tracked insulin sensitivity, and conducted oral glucose tolerance tests

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The approval was supported by the Phase III VISIBLE 2 study, where a statistically significant proportion of patients receiving 108 mg of Entyvio SC maintenance therapy administered every two weeks achieved long-term clinical remission compared to the placebo group after 52 weeks