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For MSA, twelve eigenvectors were used to classify the particles into four separate classes, which were then aligned and averaged using the TOM toolbox programs 118

Because of their relative concentrations, a small fractional conversion of ATP to AMP in the RBC yields a large relative increase in AMP concentration, which activates PFK-1

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Figure 5 T2DM is a multifactorial metabolic disease characterized by chronic hyperglycemia and dyslipidemia, which can induce long-term low-grade inflammation and oxidative stress, ultimately leading to extensive damage to target organs ( Insulin resistance in T2DM often progresses from prediabetes and impairs pancreatic buffering activity during hyperglycemia, and this insulin resistance can extend to the brain ( In conclusion, there is a strong association between the pathophysiological mechanisms of T2DM and cognitive dysfunction